Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol‐4‐phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will discuss selected examples of the findings that in the last few years have significantly increased our awareness of the regulation and roles of PI4P in the Golgi complex and beyond. We will also highlight the role of PI4P in infection and cancer. We believe (...) that, with the increasing number of regulators and effectors of PI4P identified, the time is ripe for a more integrated approach of study. A first step in this direction is the delineation of PI4P‐centered molecular networks that we provide using data from low and high throughput studies in yeast and mammals. (shrink)

This paper discusses the concept of climate in relation to architectural space. By elaborating on the notion of atmosphere, that today permeates a wide range of architectural research, I intend to expand its relevance by outlining a relationship between atmosphere and climate analogous to what occurs in meteorological studies. While climate represents a rather stable (if evolving) cycle of recurring conditions, atmospheric events are fleeting and less predictable. Equally, architectural spaces can establish a general climatic scaffolding that increases the possibility (...) of particular atmospheres to unfold, without however evolving into a deterministic cause-effect relationship. By addressing and comparing philosophical notions and architectural questions, I intend to formulate a novel theorisation as a useful tool for both criticism and design. (shrink)

This paper discusses the concept of climate in relation to architectural space. By elaborating on the notion of atmosphere, that today permeates a wide range of architectural research, I intend to expand its relevance by outlining a relationship between atmosphere and climate analogous to what occurs in meteorological studies. While climate represents a rather stable (if evolving) cycle of recurring conditions, atmospheric events are fleeting and less predictable. Equally, architectural spaces can establish a general climatic scaffolding that increases the possibility (...) of particular atmospheres to unfold, without however evolving into a deterministic cause-effect relationship. By addressing and comparing philosophical notions and architectural questions, I intend to formulate a novel theorisation as a useful tool for both criticism and design. (shrink)

Étudier les actes de requête dans les discours prononcés aux Nations Unies s’avère d’une utilité certaine dans le travail de caractérisation de ce sous-genre diplomatique. La formulation indirecte des actes de langage et les procédés linguistiques qui éloignent les sources potentielles de confrontation révèle des discours contraints par l’exercice de la « politesse », au service de l’impératif institutionnel de valorisation du consensus. Ces discours qui s’éloignent du fonctionnement du langage ordinaire transfèrent la prise en charge de l’énonciation aux États-membres (...) qui sont ici de véritables locuteurs et qui partant parlent en leur propre nom. L’on observe alors l’impact d’un contexte socio-discursif sur le fonctionnement de langue. Les requêtes formulées dans ces discours reflètent les problématiques qui préoccupent les États membres, puisque dans bien des cas, une requête peut être l’aveu d’un manque. Les verbes illocutoires donnent un bon aperçu des « façons de parler » et témoignent d’ores-et-déjà d’une routinisation des pratiques langagières. (shrink)

The Covid-19 pandemic has been analysed and discussed from many disciplinary perspectives. An aspect that still needs critical exploration is the role—that is, the modes and forms—of regulatory interventions during the pan- demic. It is interesting to note in this regard that, in many studies, regulatory measures are labelled “non-pharma- ceutical interventions”, as if they do not have any specificity on their own and only represent a theoretically residual category. The main aim of this article is instead to focus on (...) the distinctive features of normative measures as such. As regards the article’s focus, it centres on the normative interventions in the first period of the pandemic—that is, 2020—with particular reference to Italy. We have chosen to focus on this period because the most extensive and severe restrictions introduced to combat Covid-19 were established at that time. And we have chosen to con- sider Italy because it was the first country, after China, to be hard hit by the virus and to react in a draconian manner. As regards the methodology, the article is based, in general and primarily, on an extensive interdisciplinary literature review. With reference to the Italian case, the study is additionally based on: first-hand data collection and analysis (especially concerning Italian normative measures mainly issued at the national level: their type, frequency, target, hierarchical relationships); second-hand data and analysis (for instance as regards the effectiveness of Italy’s and other countries’ regulatory measures). In discussing the Italian response to the Covid-19 pandemic, certain weaknesses have been identified; and possible lessons have been highlighted, in terms of both “planning” (i.e. the necessity to better pre-define concrete and circumscribed sets of actions) and of “meta-planning” (i.e. the necessity of better planning the way in which public authorities could and should plan and act). Although this article is mainly based on the Italian situation, what we can learn from this case is largely generalizable. (shrink)

ABSTRACT:Although the literature on multi-stakeholder initiatives for sustainability has grown in recent years, it is scattered across several academic fields, making it hard to ascertain how individual disciplines, such as business ethics, can further contribute to the debate. Based on an extensive review of the literature on certification and principle-based MSIs for sustainability, we show that the scholarly debate rests on three broad themes : theinputinto creating and governing MSIs; theinstitutionalizationof MSIs; and theimpactthat relevant initiatives create. While our discussion reveals (...) the theoretical underpinnings of the 3Is, it also shows that a number of research challenges related to business ethics remain unaddressed. We unpack these challenges and suggest how scholars can utilize theoretical insights in business ethics to push the boundaries of the field. Finally, we also discuss what business ethics research can gain from theory development in the MSI field. (shrink)

v. 1. Scritti di gnoseologia. Scritti di filosofia prima -- v. 2. Scritti di fenomenologia. Scritti di ermeneutica.

Given the food challenges that society is facing, we draw upon recent developments in the study of how food reputation affects food preferences and food choices, providing here a starting standard point for measuring every aspect of food reputation in different cultural contexts across the world. Specifically, while previous attempts focused either on specific aspects of food or on measures of food features validated in one language only, the present research validates the Food Reputation Map (FRM) in Italian, English and (...) Chinese over 2250 participants worldwide. Here we successfully measure food reputation across twenty-three specific indicators, further grouped into six synthetic indicators of food reputation. Critically, results show that: a) the specific measurement tool of food reputation can vary across cultural contexts, and that b) people’s reputation of food products or categories changes significantly across different cultural contexts. Therefore, in order to understand people’s food preferences and consumption, it is important to take into account the repertoire of cultural differences that underlies the contexts of analysis: the three context-specific versions of the FRM presented here effectively deal with this issue and provide reliable context-specific insights on stakeholders’ interests, perspectives, attitudes and behaviors related to food perceptions, assessment and consumption, which can be effectively leveraged to foster food sustainability. (shrink)

As artefacts, the worlds of digital games are designed and developed to fulfil certain expressive, functional, and experiential objectives. During play, players infer these purposes and aspirations from various aspects of their engagement with the gameworld. Influenced by their sociocultural backgrounds, sensitivities, gameplay preferences, and familiarity with game conventions, players construct a subjective interpretation of the intentions with which they believe the digital game in question was created. By analogy with the narratological notion of the implied author, we call the (...) figure to which players ascribe these intentions ‘the implied designer’. In this article, we introduce the notion of the implied designer and present an initial account of how appreciators ascribe meaning to interactive, fictional gameworlds and act within them based on what they perceive to be the designer’s intentions. (shrink)

The present work is a contribution towards understanding the cultural environment in which the concept of man and nature were conceived in India. The book has the virtue of presenting the Hindu philosophical systems in a style that is intelligible for even neophytes.

Philologus, founded in 1846, is one of the oldest and most respected periodicals in the field of Classics. It publishes articles on Greek and Latin literature, historiography, philosophy, history of religion, linguistics, reception, and the history of scholarship. The journal aims to contribute to our understanding of Greco-Roman culture and its lasting influence on European civilization. The journal Philologus, conceived as a forum for discussion among different methodological approaches to the study of ancient texts and their reception, publishes original scholarly (...) contributions with a strong international focus. Publications languages are: German, English, Italian, French. As of 2014 the publication of supplementary volumes will be resumed. The series Philologus. Supplemente / Philologus. Supplementary Volumes will publish monographs and edited volumes pertaining to all aspects of the study of ancient literature and its reception, with a special focus on topics concerning literary theory, philosophy and the history of scholarship from an interdisciplinary perspective. (shrink)

This paper focuses on the role of punishment as a critical social mechanism for cheating prevention in MMORPGs. The role of punishment is empirically investigated in a case study of the MMORPG Tibia and by focusing on the use of bots to cheat. We describe the failure of punishment in Tibia, which is perceived by players as one of the elements facilitating the proliferation of bots. In this process some players act as a moral enterprising group contributing to the reform (...) of the game rules and in particular to the reform of the Tibia punishment system by the game company. In the conclusion we consider the ethical issues raised by our findings and we propose some general reflections on the role of punishment and social mechanisms for the governance of online worlds more generally. (shrink)

The Jesuit theologian, Francisco Suarez, is know as the «father of modern scientific Mariology» because of the innovations he brought to the Scholastic treatment of the Virgin Mary. Commenting on the third part of the Summa Theologica of St. Thomas, at the Roman College in 1584-85, he developed 24 questions under the title De Deipara et Christo ut eius Filio, material which to this day has remained unpublished. In the present essay, the author discusses the role of Mary in the (...) life and works of Suarez, revealing his faith in the Immaculate Conception and at the same time the need to establish in the Virgin the human debt or necessary participation in Original Sin. Then he deals with Suarez's 24 questions, material conserved in the archives of the Pontifical Gregorian University. In these questions, he insists, we find the first systematic treatise on Mary, a work which demonstrates a logical and unitary division, clearly different from the chronological order of Thomas's Summa. Suárez divides his work into three parts: the dignity of the Mother of God, her perfection in body and soul, and the veneration due to her. (shrink)

Drawing from narratology and design studies, this article makes use of the notions of the ‘implied designer’ and ‘ludic unreliability’ to understand deceptive game design as a specific sub-set of transgressive game design. More specifically, in this text we present deceptive game design as the deliberate attempt to misguide players’ inferences about the designers’ intentions. Furthermore, we argue that deceptive design should not merely be taken as a set of design choices aimed at misleading players in their efforts to understand (...) the game, but also as decisions devised to give rise to experiential and emotional effects that are in the interest of players. Finally, we propose to introduce a distinction between two varieties of deceptive design approaches based on whether they operate in an overt or a covert fashion in relation to player experience. Our analysis casts light on expressive possibilities that are not customarily part of the dominant paradigm of user-centered design, and can inform game designers in their pursuit of wider and more nuanced creative aspirations. (shrink)

Part of the generalizability issues that haunt controlled lab experiment designs in psychology, and more particularly in psycholinguistics, can be alleviated by adopting corpus linguistic methods. These work with natural data. This advantage comes at a cost: in corpus studies, lexemes and language users can show different kinds of skew. We discuss a number of solutions to bolster the control.

Restoration involves individuals’ physical, psychological and social resources, diminished by meeting demands of everyday life. Psychological restoration can be provided by specific environments, in particular by natural environments. Research reports a restorative effect of nature on human beings, specifically in terms of the psychological recovery from attention fatigue and restored mental resources previously spent in activities that require attention. Two field studies in two Italian primary schools tested the hypothesized positive effect of recess-time spent in a natural (vs. built) environment (...) on pupils’ cognitive performance and their perceived restorativeness, using standardized tests. In Study 1, children’s psychological restoration was assessed measuring sustained and selective attention, working memory, and impulse’ control, before and after morning recess-time. Team standardized play-time was conducted in a natural (vs. built) environment, measuring perceived restorativeness after each recess-time. Results showed a greater increase in sustained and selective attention, concentration, and perceived restorativeness from pre-test to post-test after the Natural Environment condition. In Study 2 the positive effect of free-play recess-time in a natural (vs. built) environment was assessed during the afternoon school-time on sustained and selective attention and perceived restorativeness. Results showed an increase of sustained and selective attention after the Natural Environment condition (vs. Built) and a decrease after the built environment break. Higher scores in perceived restorativeness were registered after the Natural (vs. Built) Environment condition. Team standardized and individual free-play recess in a natural environment (vs. built) support pupils’ attention restoration during both morning and afternoon school-time, as well as their perceived restorativeness of recess environment. Theoretical and practical implications are discussed in terms of nature’s role both for school ground design or re-design, and for school’s activities organization. (shrink)

Morality is often defined in opposition to the natural "instincts," or as a tool to keep those instincts in check. New findings in neuroscience, social psychology, animal behaviour, and anthropology have brought us back to the original Darwinian position that moral behaviour is continuous with the social behavior of animals, and most likely evolved to enhance the cooperativeness of society. In this view, morality is part of human nature rather than its opposite. This interdisciplinary volume debates the origin and working (...) of human morality within the context of science as well as religion and philosophy. Experts from widely different backgrounds speculate how morality may have evolved, how it develops in the child, and what science can tell us about its working and origin. They also discuss how to deal with the age-old facts-versus-values debate, also known as the naturalistic fallacy. The implications of this exchange are enormous, as they may transform cherished views on if and why we are the only moral species. (shrink)

Aim of the paper is contributing to a context-informed understanding of Fichte’s theory of conscience. This crucial element in his moral philosophy (and, in fact, in his whole philosophy) represents the last of the many significant accounts of conscience in the 18th century, before in the following century the role of conscience in moral life was repeatedly put into question. Accordingly, in my paper I argue that: (1) Fichte puts forward an un-Kantian account of conscience, following, instead, a quite different (...) model; (2) Fichte’s views on conscience grew out of a complex conceptual milieu, from which Fichte borrows important (quasi-)sentimentalist elements; (3) Fichte’s idea of the infallibility of conscience must be distinguished from other similar views put forward in the same years. (shrink)

Italian Sounding—i. e., the Italian appearance of a product or service brand irrespective of its country of origin—represents a global market phenomenon affecting a wide range of economic sectors, particularly the agro-food sector. Although its economic impact has been repeatedly stressed from different points of view, systematic scientific knowledge regarding its social–psychological bases is lacking. Three studies carried out in three different countries address this literature gap. Different consumer groups are targeted regarding major product categories pre-selected categories, which are the (...) major Italian food goods within the specific country according to piloting. In each study, the main independent variable has been manipulated by presenting real product images, whose “Italianness” degree is effectively manipulated by the main study variable across three or four levels. Main hypotheses are tested via a survey with the specific product images administered to samples in Italy, China, and the USA. Across the three studies, results show that Made in Italy products, compared to the other ones, are advantaged in terms of the main dependent variables: reputation profile, general reputation, attitude, and willingness to pay. Moreover, Italian Sounding products are endowed with corresponding significant advantages when compared to the Generic Foreign by non-Italian samples. Results reveal the specific social–psychological profile of Italian Sounding products in terms of either weaknesses or strengths when compared to both Made in Italy products and Generic Foreign ones, differently in the eyes of Italian and non-Italian consumers across different countries. Finally, consistently across the three studies, the extent to which a food product is perceived to be Italian increases consumers' WTP for that product, and this effect is consistently mediated by the product's reputation. (shrink)